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butabarbital will reduce the level or outcome of nifedipine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Significance Unfamiliar.butabarbital will lower the extent or influence of pioglitazone by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Small/Importance Unfamiliar.butabarbital will lower the extent or effect

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